Ernst Mayr on species classification in philosophy of biology

The assumptions of population thinking are diametrically opposed to those of the typologist. The populationist stresses the uniqueness of everything in the organic world. What is true for the human species,–that no two individuals are alike, is equally true for all other species of animals and plants ... All organisms and organic phenomena are composed of unique features and can be described collectively only in statistical terms. Individuals, or any kind of organic entities, form populations of which we can determine the arithmetic mean and the statistics of variation. Averages are merely statistical abstractions, only the individuals of which the populations are composed have reality. The ultimate conclusions of the population thinker and of the typologist are precisely the opposite. For the typologist, the type (eidos) is real and the variation. an illusion, while for the populationist the type (average) is an abstraction and only the variation is real. No two ways of looking at nature could be more different.

--In What Evolution is, quoted from 1959.

Aloha Friday: 2013 Merrie Monarch Festival and E Pili Mai

Mili Hokoana English, of Maui, won the Merrie Monarch 50th anniversary hula dance competition yesterday in Hilo.

Merrie Monarch is a yearly hula dance festival here.

Here's a link to a Youtube recording of a different version of the song (Mili's version had two original verses) .

E Pili Mai (Come To Me) - Words by Larry Lindsey Kimura, Music by Cyril Pahinui

ʻAuhea wale ana ʻoe
Kuʻu lei o ka pō
Pō anu hoʻokahi nō au
Sweetheart mine
E pili mai

Inā ʻo ʻoe a ʻo au
ʻIke i ke ahi o Makana
He makana ia na ke aloha
No na kau a kau
ʻO ʻoe aʻo au
Sweetheart mine
E pili mai
Where are you
My sweetheart of the night
The night is cold and I am alone
Sweetheart mine
Come to me

If you and I are together
We'll know the fires of Makana
It would be a gift given of love
For all time
You and I
Sweetheart mine
Come to me

New Concussion Guidelines: If In Doubt, Sit it Out

"If In Doubt, Sit it Out" was the slogan of an NFL concussion training video a couple of years ago, required viewing for NFL players in view of highly publicized cases of depression and encephalopathy in older American football players. Now, the American Academy of Neurology has endorsed more conservative and stringent handling of concussion at the high school level as well, where there is some evidence players may be even more vulnerable to sequelae of TBI.

The new guidelines are available here.

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A Handout For Sports Personnel:  See also HERE.
 Use this guide to help you evaluate if someone may have a concussion and needs to see a licensed health care provider.*
EVALUATE
Know these signs and symptoms of concussion. Every athlete is unique and may experience different combinations of reactions.
Common Signs of Concussion— Things You Can Observe
• Behavior or personality changes
• Blank stare, dazed look
• Changes to balance, coordination, or reaction time
• Delayed or slowed spoken or physical responses
• Disorientation (confused about time, date, location, game)
• Loss of consciousness (blackout) (occurs in less than 10 percent of people with concussion)
• Memory loss of event before, during, or after injury occurred
• Slurred/unclear speech
• Trouble controlling emotions
• Vomiting
Symptoms of Concussion— Things the Athlete Tells You
• Blurry vision/double vision
• Confusion
• Dizziness
• Feeling hazy, foggy, or groggy
• Feeling very drowsy, having sleep problems
• Headache
• Inability to focus, concentrate
• Nausea (stomach upset)
• Not feeling right
• Sensitivity to light or sound
TAKE ACTION

What should I do if an athlete has a head injury during a game?
Immediately address safety concerns. If the person is unconscious (knocked out), check his or her Airway, Breathing, and Circulation (ABCs).
Airway: Check that the mouth and throat are not blocked
Breathing: Be sure the person is breathing normally
Circulation: Check that the person’s heart is beating regularly
If you suspect the person may have a neck injury or if the person is unconscious:
• Do not move the head, neck, or spine. This could worsen any spinal injury to the neck
• Contact emergency medical services with any concern about breathing, circulation, or spinal injury
• Do not let the athlete return to play until examined and cleared by a licensed health care provider trained in diagnosing and managing concussion
SEEK CARE
What should I do if it appears the athlete has a concussion?
If a concussion is suspected, remove the athlete from play. If a concussion is diagnosed, the athlete should not return to play for the rest of the day.
• Monitor the athlete for the next three to four hours. You may need to monitor for a longer time
• Notify a licensed health care provider trained in diagnosing and managing concussion
• Do not let the athlete return to play until evaluated and cleared by a licensed health care provider trained in diagnosing and managing concussion
When is it okay for the athlete to return to the game?
Clearance from a licensed health care provider trained in diagnosing and managing concussion is needed before allowing the athlete to return to play. The health care provider may:
• Advise the athlete to return to physical activity slowly
• Explain the process for this clearly
• Tell the athlete to increase activity levels carefully, step by step
Remember, if the person has any concussion symptoms, he or she should not advance to the next activity level. Before full return to play, the final activity level should imitate game conditions as much as possible.

Cranial Vein Procedures Found Not Effective in Multiple Sclerosis

To the surprise of almost no one in North America, using a balloon catheter to correct small areas of vein narrowing when found in the heads of persons with MS does not help their multiple sclerosis, according to a small but (finally) well controlled trial. So far, I only have read a description of a poster presentation at the San Diego meeting this weekend, with nothing more on the details to read today. Hopefully a full paper will be vetted soon enough.

Those of us who were investigating new treatments back in the eighties will remember the Los Angeles surgeon who got in big trouble for performing vertebral artery surgery on MS patients over 25 years ago. Vascular theories of MS recur periodically, and given the distribution of the lesions, there may be a truth in there somewhere. But it is not likely to do with the kinds of arteries or veins one can fix with a knife or a catheter.

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POSTER

P04.273– “Percutaneous Transluminal Venous Angioplasty (PTVA) is Ineffective in Correcting Chronic Cerebrospinal Venous Insufficiency (CCSVI) and May Increase Multiple Sclerosis (MS) Disease Activity in the Short Term: Safety and Efficacy Results of the 6–Month, Double–Blinded, Sham–Controlled, Prospective, Randomized Endovascular Therapy in MS (PREMiSe) trial” – Robert Zivadinov, Buffalo, NY

Averaging and Contrast Artifacts on fMRI

Problems that occur via volume averaging and the noise increases with software-based upward adjustments of contrast have long been known to limit CT and MRI scans of the brain when looking at smaller regions for changes. fMRI researchers people are only now starting to notice this kind of artifact in their findings. This is a good sign, though, that the field may be maturing.

One further suggestion to help reliable anatomic localization is to replicate findings in other patients and with other equipment. There is still too little replication of scattered reports in the field.

Here.

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ABSTRACT

Matthew D. Sacchet, Brian Knutson, Spatial smoothing systematically biases the localization of reward-related brain activity, NeuroImage, Volume 66, 1 February 2013, Pages 270-277, ISSN 1053-8119, 10.1016/j.neuroimage.2012.10.056.

(http://www.sciencedirect.com/science/article/pii/S1053811912010592)

Neuroimaging methods with enhanced spatial resolution such as functional magnetic resonance imaging (FMRI) suggest that the subcortical striatum plays a critical role in human reward processing. Analysis of FMRI data requires several preprocessing steps, some of which entail tradeoffs. For instance, while spatial smoothing can enhance statistical power, it may also bias localization towards regions that contain more gray than white matter. In a meta-analysis and reanalysis of an existing dataset, we sought to determine whether spatial smoothing could systematically bias the spatial localization of foci related to reward anticipation in the nucleus accumbens (NAcc). An activation likelihood estimate (ALE) meta-analysis revealed that peak ventral striatal ALE foci for studies that used smaller spatial smoothing kernels (i.e. < 6 mm FWHM) were more anterior than those identified for studies that used larger kernels (i.e. > 7 mm FWHM). Additionally, subtraction analysis of findings for studies that used smaller versus larger smoothing kernels revealed a significant cluster of differential activity in the left relatively anterior NAcc (Talairach coordinates: − 10, 9, − 1). A second meta-analysis revealed that larger smoothing kernels were correlated with more posterior localizations of NAcc activation foci (p < 0.015), but revealed no significant associations with other potentially relevant parameters (including voxel volume, magnet strength, and publication date). Finally, repeated analysis of a representative dataset processed at different smoothing kernels (i.e., 0–12 mm) also indicated that smoothing systematically yielded more posterior activation foci in the NAcc (p < 0.005). Taken together, these findings indicate that spatial smoothing can systematically bias the spatial localization of striatal activity. These findings have implications both for historical interpretation of past findings related to reward processing and for the analysis of future studies.

Keywords: Nucleus accumbens (NAcc); Ventral striatum (VS); Spatial smoothing; Functional magnetic resonance imaging (fMRI); Reward; Monetary incentive delay (MID) task

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Aloha Friday: Ledward Kaapana


The classic Ku'uipo Onaona, here (youtube).


Appropriate for me, given that Maryruth is off on the mainland visiting relatives this week.

Ku`u Ipo Onaona - Madeline Lam

Auhea wale `oe e ku`u ipo lâ
Eia mai au ke kali nei lâ
Mai lohi mai `oe e ku`u ipo lâ
E ala wiki mai `oe
`O `oe no ka`u i mana`o ai lâ
He mea nui `oe na ka pu`uwai lâ
Hau`oli au i kou leo nahenahe
Kou leo me ke aloha
Ka`a puni aku a puni ka honua lâ
A `ike i ka nani o nâ pua like `ole
`A`ole no e like me `oe
E ku`u ipo onaona
Ha`ina `ia mai ana ka puana lâ
Eia mau au ke kali nei lâ
Mai lohi mai `oe e ku`u ipo lâ
E ala wiki mai `oe
Listen, my sweetheart, this is for you
Here I wait
Come, don't be slow, sweetheart
Hurry to me

You are always on my mind
You overwhelm my heart
Your gentle voice gives me pleasure
Your voice of love

I've travelled the world
Seen the beauty of flowers rare
None can compare to you
My lovely sweetheart

Tell the refrain
Here I wait
Come, don't be slow, sweetheart
Hurry to me

Lala

You can tell the hurricane is missing the island because the wind chimes are still there, instead of ripped free.