More evidence that coffee consumption may be neuroprotective.

Drink your morning coffee, and don't skimp on it, says this article from the AHA journal Circulation this November.

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Abstract

CIRCULATIONAHA.115.017341

Published online before print November 16, 2015,

doi: 10.1161/CIRCULATIONAHA.115.017341

Association of Coffee Consumption with Total and Cause-Specific Mortality in Three Large Prospective Cohorts

Running title: Ding et al.; Coffee and Total and Cause-specific Mortality Authors: Ming Ding, MD; Ambika Satija, BA; Shilpa N. Bhupathiraju, PhD; Yang Hu, MS ;Qi Sun, MD, DSc; Jiali Han, DSc; Esther Lopez-Garcia, PhD; Walter Willett, MD, DrPH; Rob M. van Dam, PhD; Frank B. Hu, MD, PhD

Background—The association between consumption of caffeinated and decaffeinated coffee and risk of mortality remains inconclusive.

Methods and Results—We examined the associations of consumption of total, caffeinated, and decaffeinated coffee with risk of subsequent total and cause-specific mortality among 74,890 women in the Nurses’ Health Study (NHS), 93,054 women in the NHS 2, and 40,557 men in the Health Professionals Follow-up Study. Coffee consumption was assessed at baseline using a semi-quantitative food frequency questionnaire. During 4,690,072 person-years of follow-up, 19,524 women and 12,432 men died. Consumption of total, caffeinated, and decaffeinated coffee were non-linearly associated with mortality. Compared to non-drinkers, coffee consumption one to five cups/d was associated with lower risk of mortality, while coffee consumption more than five cups/d was not associated with risk of mortality. However, when restricting to never smokers, compared to non-drinkers, the HRs of mortality were 0.94 (0.89 to 0.99) for 1 cup/d, 0.92 (0.87 to 0.97) for 1.1-3 cups/d, 0.85 (0.79 to 0.92) for 3.1-5 cups/d, and 0.88 (0.78 to 0.99) for > 5 cups/d (p for non-linearity = 0.32; p for trend < 0.001). Significant inverse associations were observed for caffeinated (p for trend < 0.001) and decaffeinated coffee (p for trend = 0.022).

Significant inverse associations were observed between coffee consumption and deaths due to cardiovascular disease, neurological diseases, and suicide. No significant association between coffee consumption and total cancer mortality was found.

Conclusions—Higher consumption of total coffee, caffeinated coffee, and decaffeinated coffee was associated with lower risk of total mortality.